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ASMS 2021 Poster

Preliminary Evaluation of an Extended Mass Range Ion Mobility Spectrometer Determines CCS of Small Proteins to AAV’s

· Ion Mobility,ESI,Native

The performance of a simple benchtop spectrometer was benchmarked for characterizing particles with CCS from 10-1000 nm2, equivalent to particle diameter from 3 - 30 nm or K between 0.2 and 0.002 potentially extends ion mobility spectrometry to the range of sizes encountered by the new high mass biotherapeutic modalities that includes AAV’s, mRNA and lipid nanoparticles, along with large protein complexes such as lipoproteins.

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